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Combinatorial biosynthesis of HDAC inhibitors: the code of the docking domains elucidated
A team from Warwick and Monash identifies the molecular mechanism that lets bacteria assemble an à la carte family of depsipeptide anticancer agents — a foundation for engineering variants, still far from the clinic.
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NeuroVFM: a neuroimaging foundation model trained on the hospital's raw data
A 3D model whose encoder is trained without labels on 5.24 million routine CT and MRI volumes reaches 92.68% AUROC across 82 CT diagnoses and 92.49% across 74 MRI diagnoses. With the archive held identical, it is the training objective — latent-space prediction — that opens the gap.
The Bessemer Process — Mass Steel Transforms Civilization
On 13 August 1856, Henry Bessemer presented to the British Association for the Advancement of Science a process that converts 5 tonnes of pig iron into steel in 20 minutes by blowing air through it — cutting the price of steel by a factor of 6 to 8, from ~£40-60 to £7 per tonne.
AlphaFold 3 — Universal Prediction of Biomolecular Interactions
In May 2024, DeepMind publishes AlphaFold 3. Beyond isolated proteins, the model predicts the structures of protein–DNA, protein–RNA, and protein–ligand complexes with accuracy surpassing all existing methods — opening the door to large-scale computational drug design.