To edit a genome better, first switch off the genes that slow delivery down
Rather than refining the editing tool yet again, a Wisconsin team turned the question around: which human genes prevent the tool from reaching its destination? A screen across 19,114 genes points to six. Switching off just one of them, GJB2, raises correction of a blinding mutation from 5.8% to 46.6% in patient-derived retinal cells, and restores measurable electrical activity to the faulty ion channel in a fraction of the edited cells. Cell-culture work: nothing has yet been tested in an organism.
Severe COVID wakes dormant viruses — and one of them marks long COVID
Across 1,154 hospitalized patients, nearly one in two sees a dormant chronic virus reactivate during acute COVID — herpes, cytomegalovirus, Epstein-Barr, but also the inconspicuous anelloviruses. The latter are associated, during convalescence, with the form of long COVID marked by physical disability. Association, not causation: the authors say so in black and white.